For example, PIWIL1 (piwi-like RNA-mediated gene silencing 1) plays a central role in spermatogenesis and was found to be differentially methylated in infertile patients [34], while lack of SYCP1 (synaptonemal complex protein 1) in otherwise healthy mice has been found to yield infertility [35]. Here, SYCP1 is linked to Infertility.