Approximately 10 % of melanomas occur in a familial setting, and germline mutations to a number of genes, including CDKN2A (9p21), CDK4 (12q14), BAP1 (3p21), TERT promoter (5p15) [26], and most recently POT1 (7q31) [27], have been demonstrated to predispose individuals to developing cutaneous melanoma in addition to other melanoma subtypes (e.g., BAP1 and metastatic uveal melanoma) as well as numerous atypical melanocytic nevi (CDKN2A, CDK4) [28]. The gene discussed is CDKN2A; the disease is cutaneous melanoma.