Genomic evidence that epigenetic regulators may contribute to melanoma pathogenesis was recently highlighted by Hodis et al. [20], who found a high frequency of somatic mutations in chromatin-modifying proteins and other epigenetic regulators as well as a high frequency of UVB-signature mutations in IDH1 and chromatin-modifying enzymes ARID2 (a component of the SWI/SNF chromatin-remodeling complex) and EZH2 (the histone lysine methylase component of Polycomb-group gene silencing complex). The gene discussed is ARID2; the disease is melanoma.