CASP3 and hepatocellular carcinoma: Solamargine is one of the major compounds present in AE-SN that can activate caspase-3-related apoptosis and LC-3-A/B-II-related autophagy in human leukemia cells [22], and a 150 kDa glycoprotein isolated from AE-SN was reported to be another effective antitumor compound for activating caspase-3-related apoptosis in human colorectal, cervical, and HCC cells [23–25].