NFKB1 and gout: Immunohistochemical results showed that in MSU crystal-induced gouty arthritis rats pretreated with vehicle (model) the positive expression of NF-κB p65 in the synovium sections was significantly increased compared with control group (P < 0.01) (Figure 3(b), Table 1) and NF-κB p65 expression was observed in the cytoplasm and the nucleus.