Conspicuously, we notice that 5 genes (CDK6, E2F3, CCND1, SMAD4 and CDKN1B) are associated with cell cycle, colorectal cancer, pancreatic cancer, chronic myeloid leukemia, and small cell lung cancer in the cluster of Group A (Figure 4(c)). This evidence concerns the gene SMAD4 and chronic myelogenous leukemia, BCR-ABL1 positive.