CDKN1B and familial pancreatic carcinoma: Conspicuously, we notice that 5 genes (CDK6, E2F3, CCND1, SMAD4 and CDKN1B) are associated with cell cycle, colorectal cancer, pancreatic cancer, chronic myeloid leukemia, and small cell lung cancer in the cluster of Group A (Figure 4(c)).