Specifically these studies have demonstrated that the presence of a single nucleotide polymorphism (SNP) at the IL28B locus, specifically the presence of the T alleles of rs12979860 or the G alleles of rs8099917 is associated with a reduced response to PegIFN/RBV therapy and importantly also an increased prevalence of PBMC infection (OR: 3.564; 95% CI: 1.114–11.40, P = 0.0437) [98, 102–104]. This evidence concerns the gene IFNL3 and infection.