Alzheimer’s disease, progressive supranuclear palsy, corticobasal degeneration and several other neurodegenerative diseases are characterized by the presence of intracellular aggregates of microtubule-associated protein tau leading to their grouping under the name of tauopathies (Spillantini and Goedert, 2013). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.