With this in mind, we decided to re-investigate the observation by Nica et al. [1] that the INS-IGF2 fusion transcript was found to be the second most abundant mRNA in human beta cells, an observation that has generated much interest in the beta cell biology field since INS-IGF2 has previously been annotated to be translated [2] and moreover, recently proposed as a novel autoantigen in Type 1 Diabetes (T1D) [3]. This evidence concerns the gene INS and type 1 diabetes mellitus.