Evidence shows that the miR-221/222 cluster promotes EMT by repressing expression of the trichorhinophalangeal syndrome 1 (TRPS1) protein, which in turn results in an increase of the EMT-promoting protein zinc finger E-box binding homeobox 2 (ZEB2), thus potentially contributing to the more aggressive clinical behaviour of basal-like breast cancer [136]. Here, ZEB2 is linked to breast carcinoma.