However, it is important to note that the prognostic impact of the presence of a BRAF mutation is dependent on the microsatellite status: whereas microsatellite-stable BRAF mutated CRC are associated with a worse, microsatellite-instable BRAF mutated tumors are associated with a better prognosis than BRAF wild type CRC [21]. This evidence concerns the gene BRAF and colorectal carcinoma.