MDM2 and cancer: Recently, we showed that induction of p53 protein using doxorubicin, 5-fluorouracil, UV, ionizing radiation and MDM2 inhibitor Nutlin-3 can modify expression of TLRs and enhance expression of IL1B, IL6 and IL8 cytokines in response to TLR ligands in human primary blood cells and cancer cell lines [2, 3].