As LARGE2, the product of GYLTL1B, has recently been identified as a critical enzyme for DG glycosylation in prostate cancer, and GYLTL1B was the most strongly downregulated gene in ccRCC, we sought to examine the hypothesis that hypermethylation of the GYLTL1B promoter region might contribute to its downregulation utilizing the TCGA database [22]. This evidence concerns the gene LARGE2 and Familial prostate cancer.