NOTCH1 and acute lymphoblastic leukemia: In addition, contradictory results have been reported in pediatric and adult patients for the impact of the abnormalities in the NOTCH1/FBXW7-mutated subgroup,13, 14 which is important for clinical application as at least some studies have shown that patients with NOTCH1/FBXW7 mutations do particularly well.6, 7, 8 There is also no information on the impact of RAS mutations in pediatric T-ALL, although in adult patients, they were associated with worse outcome and were included as poor risk in an oncogenetic classifier strategy.14