FOXO1 and Hepatic fibrosis: Conversely, when IKK2 is superactivated in fasting liver or neonatal liver, where IKK1 is low and FOXO1 activity is high [42], FOXO1 synergizes with p65/p50 to cause insulin resistance and induce proinflammatory IL-1β, IL-6, CCL2, and CCL20, resulting in progressive inflammation and/or liver fibrosis [5].