Two recent studies demonstrate that neonatal hepatocyte-specific superactivation of IKK2-NF-kB causes progressive inflammation and liver fibrosis at adulthood [5], whereas hepatocyte-specific activation of IKK2-NF-kB by transgenic expression of Ikk2ca driven by a strong albumin promoter causes inflammation and insulin resistance without liver fibrosis [6]. The gene discussed is IKBKB; the disease is Hepatic fibrosis.