The tumor treated with Trabectedin/α-PD-1 mAb also exhibited the decreased protumor TAM/MDSC and Treg recruitment/accumulation and (i.e., reduced transcript expression for CCL2, CXCL12, CD14, M-CSFR and FoxP3; Fig. 4b) and function (i.e., decreased expression of transcripts for IL-1β, IL-6, IL-10, TGF-β and VEGF as well as the MDSC-associated gene products arginase-1 and iNOS; Fig. 4c). The gene discussed is CXCL12; the disease is neoplasm.