As for their application in OC, a clinical trial including a small cohort of OC patients demonstrated that treatment with α-PD-L1 antibody induced a durable antitumor response in a minority of patients (1 partial response and 3 stable disease in 17 patients lasting for at least 24 weeks) [16]; additionally, α-CTLA4 antibody ipilimumab has also been reported to increase antitumor effect of GM-CSF-modified autologous tumor cell vaccines [22, 23]. The gene discussed is CD274; the disease is neoplasm.