CD274 and neoplasm: Our data demonstrate that in vivo Trabectedin treatment induced the PD-L1 expression within tumors, which may be partially responsible for the synergistic antitumor effect of combined Trabectedin and α-PD-1 mAb as tumor PD-L1 expression disabling the antitumor function of preexisting tumor antigen-specific T cells has been thought to be prerequisite for α-PD-1 mAb therapy to work [15].