ZAP70 and B-cell chronic lymphocytic leukemia: In CLL subgroup, we further found patients with β2-MG < 3.5 mg/L, LDH < 220 U/L, ZAP-70 negative, and non high risk genetic abnormality benefited more from the R-based regimens with higher CR rate than control patients (P = 0.003, 0.029, 0.013 and 0.038) (Table 4).