In the last few years, several studies have established the contribution of single nucleotide polymorphisms (SNPs) in different genes -such as the patatin-like phospholipase-3 (PNPLA3), vitamin D receptor (VDR), transmembrane 6 superfamily member 2 (TM6SF2), beta-parvin (PARVB) and sorting and assembly machinery component 50 (SAMM50) genes- as causal variants for chronic liver diseases and their progression towards HCC [14–17]. Here, TM6SF2 is linked to hepatocellular carcinoma.