Current strategies for treatments for obesity include diets, exercise, behavioral lifestyle changes, pharmaco-therapeutic agents and bariatric surgery.16, 17, 18 Treatment of obesity with incretin, glucagon-like peptide-1 (GLP-1) receptor agonists, enzyme inhibitors, angiopoietin-like proteins has been investigated. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.