To investigate TACC3 expression in HCC, TACC3 mRNA and protein levels were analyzed by qRT-PCR assays and western blot analysis in the immortalized liver cell line LO2 and in a panel of HCC cell lines (SK-Hep-1, SMMC-7721, Bel-7402, MHCC-97L, QGY-7703, and Huh7). This evidence concerns the gene TACC3 and hepatocellular carcinoma.