The mechanism underlying positive and negative influences of LGALS3BP on the prognosis of various cancers is not understood, but may be related to the multi-domain nature of the protein and its ability to bind to different ligands, including galectins, in particular galectin-3 and 1 [26], endosialin [27] and tetraspanins [28] in different tumor tissues. The gene discussed is LGALS3BP; the disease is cancer.