LGALS3BP and neoplasm: To confirm that LGALS3BP has a suppressive role in CRC growth, tumors from HCT-116 LGALS3BP knock-down cells were injected intra-lesionally with 100 μg LGALS3PBP in 50 μL PBS or the same volume of PBS (as a control) twice a week; starting from the fifth injection of LGALS3BP, a significant reduction in tumor growth was observed (Fig. 2c).