In cancer cells, there is crosstalk between Hh and other molecular signalling pathways, including rat sarcoma viral oncogene homolog (RAS)/ rapidly accelerated fibrosarcoma (RAF)/ mitogen-activated protein kinases (MEK)/ extracellular signal regulated kinases (ERK), PI3K/v-akt murine thymoma viral oncogene homolog (AKT)/mTOR, epidermal growth factor receptor (EGFR), and Notch 19. The gene discussed is EGFR; the disease is cancer.