Cytoplasmic p-Pak2 expression in proliferative endometrium was significantly higher than that in all other categories (all P<0.05) except complex hyperplasia whereas nuclear p-Pak2 only showed significantly higher expression in proliferative endometrium than atrophic (P = 0.046) and secretory (P = 0.028) endometrium and endometrial cancers (P = 0.007) (Fig 2B). The gene discussed is PAK2; the disease is endometrial cancer.