p21-activated serine/threonine kinases (Paks) are effectors for the small Rho GTPases Rac1 and Cdc42 that play important roles in a variety of cellular functions, including cell morphogenesis, motility, survival, anchorage-independent growth and angiogenesis, all of which are prerequisite steps for tumor formation and tumor invasion [4, 5]. This evidence concerns the gene CDC42 and neoplasm.