Interestingly, we found that soluble RANKL levels were higher in breast cancer patients with AI-related MS-AEs carrying the rs7984870 CC genotype (739.3 ± 66.6 pg/ml) than those carrying the GG genotype (642.2 ± 57.8 pg/ml, p < 0.05, Fig 2A). Here, TNFSF11 is linked to breast cancer.