In summary, our data indicate that Aβ modifies the mRNA expression levels of GluN1 and mGlu1 glutamatergic subunits as expected by previous reports [20,21], but also decreases the mRNA expression levels of different subunits of two potassium channels, GirK2-4 and Kcnq2-3, that control neuronal excitability and have been recently linked to hippocampal AD pathophysiology. The gene discussed is GRM1; the disease is Alzheimer disease.