In keeping with its documented capacity to promote dendritic cell-mediated T cell activation [56] and restoration of T cell responses (e.g., IFNγ) in the setting of sepsis [30], IL-7 treatment selectively restored IFNγ release in response to tolerance and cross-tolerance following treatment with high doses of either LPS or CpGA DNA (Fig 7B). Here, IFNG is linked to Sepsis.