However, the importance of these cells in PCa progression was established in a landmark and subsequent papers (45, 66, 67) using subcutaneous Myc-CaP and spontaneous TRAMP mouse PCa models to show that castration-induced cell death and resulting hypoxia stimulated CXCL13-mediated infiltration of lymphotoxin β (LTb)-expressing B lymphocytes into regressing tumors. Here, LTB is linked to posterior cortical atrophy.