Positive: massive infiltration of Gr1+CD11b+ cells at onset of senescence induced by complete PTEN loss (with or without Docetaxel). These cells expressed IL1-RA and opposed IL-1α-induced senescence, thereby promoting tumor progression. This phenomenon was also observed in oncogene-induced tumor models. Human prostate cancer patients whose tumors express high levels of IL1-RA did not respond to Docetaxel and had shorter DFS. This evidence concerns the gene ITGAM and Familial prostate cancer.