Positive; patients with higher stage or Gleason Score prostate cancer had higher CD68+ TAM counts. Patients with PSA failure had significantly higher TAM counts than those without. Recurrence-free survival was significantly lower in patients with high TAM counts than those with low TAM counts. TAM count was determined to be a significant prognostic factor in addition to PSA, Gleason Score, extraprostatic extension, lymph node metastasis, and distant metastasis. This evidence concerns the gene CD68 and metastatic malignant neoplasm in the lymph nodes.