PNPLA2 and steatosis: Our previous studies suggests that mTORC1 protects against diet-induced steatosis in part due to elevated lipolytic activity (e.g., increased Atgl) [11]; here, we did not challenge the BDE-47 treated Tsc1−/− mice with a high-fat diet to determine the extent of steatosis ‘protection’, nor did we examine the effects of BDE-47 on total body metabolism.