Those with liver-specific activation of Akt (Ptenfl/fl;AlbCre, a.k.a. Pten−/−) are known to be hyper-sensitive to insulin, whereas those with mTORC1 activation (Tsc1fl/fl;AlbCre, a.k.a. Tsc1−/−) display mild insulin resistance. This evidence concerns the gene TSC1 and Insulin resistance.