HPSE and infection: We found that our dataset had a larger proportion of genes with significant (≥0.75) log2 fold changes relative to an uninfected control than in the previously published datasets, and those identified as DE showed DE of a higher magnitude, highlighting that by specifically analyzing Hpa-proximal cells, we observe greater sensitivity in expression changes during infection (compare the width of plots in Figures 5C,D to Figures 5E,F).