In addition, it has been shown that in aortas of mice with deoxycorticosterone acetate–salt (DOCA-salt) hypertension, ROS produced by NOXs oxidize the eNOS cofactor tetrahydrobiopterin, leading to the uncoupling of eNOS that produces superoxide rather than NO (Landmesser et al., 2003). This evidence concerns the gene NOS3 and Hypertension.