NOS3 and hypertensive disorder: In addition, it has been shown that in aortas of mice with deoxycorticosterone acetate–salt (DOCA-salt) hypertension, ROS produced by NOXs oxidize the eNOS cofactor tetrahydrobiopterin, leading to the uncoupling of eNOS that produces superoxide rather than NO (Landmesser et al., 2003).