These impressive findings contrast with the recently published Denervation of the Renal Artery in Metabolic Syndrome (DREAMs) study that prospectively reported no effect of RDN on measures of insulin sensitivity after 12-months in 29 patients with metabolic syndrome on ≤1 antihypertensive and/or diabetic medication (Verloop et al., 2015). This evidence concerns the gene INS and metabolic syndrome.