This NF-κB binding response can serve as a baseline from which to compare NF-κB response to resection during conditions of chronic inflammation caused by chronic liver diseases including alcohol use, obesity, hepatitis infection, or bile salt export pump deficiency (which causes inflammation and carcinogenesis in the absence of external, cancer-predisposing factors) (McGivern and Lemon, 2011; Sun and Karin, 2012; Iannelli et al., 2014; Kudo et al., 2014). The gene discussed is ABCB11; the disease is obesity due to melanocortin 4 receptor deficiency.