TNFRSF1A and Alzheimer disease: Aβ not only increases expression of TNFα (Meda et al., 1995; Akama and Van Eldik, 2000) but also is able to activate the TNFα receptor TNFRI, which is upregulated in AD brains compared to normal controls (Li et al., 2004; Cheng et al., 2010).