Skeletal muscles of DM2 patients also show a deregulated neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) ubiquitin ligase-PTEN pathway, which could contribute to the increased risk of statin-adverse reactions in patients with DM2, due to PTEN accumulation in highly atrophic muscle fibers (Screen et al., 2014). This evidence concerns the gene PTEN and myotonic dystrophy type 2.