On the contrary, Znf9+/– mice (lacking one CNBP allele) develop a multisystem phenotype resembling DM, including muscle wasting, heart failure and cataracts (Chen et al., 2007), which suggests that CNBP insufficiency may have a role in the pathologic mechanisms of DM2 (Raheem et al., 2010). Here, CNBP is linked to heart failure.