For example, HSA mice, which harbor 5 (short repeat length, HSASR) or 250 (long repeat length, HSALR) CTG repeats in the Human Skeletal Actin gene (HSA), thus inducing a muscle-specific expression of tandem repeat-containing RNAs, have clearly established the role of RNA-protein aggregates in the development of the disease, as mice harboring long repeats developed a DM-like phenotype of muscle degeneration (Mankodi et al., 2000). This evidence concerns the gene ALB and diabetes mellitus.