Mutations of the Caspr2 gene (cntnap2) have been unambiguously associated with neuropsychiatric disorders, such as developmental language impairment and autistic spectrum disorders (Strauss et al., 2006; Bakkaloglu et al., 2008; Penagarikano and Geschwind, 2012; Rodenas-Cuadrado et al., 2013). This evidence concerns the gene CNTNAP2 and autism spectrum disorder.