LGI1 was also considered as a possible post-synaptic receptor for Caspr2 as it is recruited within the VGKC complex where it interacts with ADAM22 and ADAM23 (Ogawa et al., 2008) and LGI1 is also involved in some autoimmune encephalitis (Lai et al., 2010). This evidence concerns the gene ADAM22 and autoimmune encephalitis.