Levels of BDNF (Dwivedi et al., 2003), GDNF (Otsuki et al., 2008; Zhang et al., 2008), and basic fibroblast growth factor (bFGF; Evans et al., 2004) are decreased in patients with depression, and relates to the reduced hippocampal neurogenesis. Here, FGF2 is linked to depressive disorder.