It has been shown that the proinflammatory cytokine interleukin 18 (IL-18) is elevated in post-mortem AD patient brains, and it modulates the tau kinases, GSK3β, and Aβ-production, strongly implying that the chronic inflammation and oxidative stress are closely related to AD pathogenesis (Sutinen et al., 2014). The gene discussed is GSK3B; the disease is Alzheimer disease.