Overall, these changes led to a significant increase in GluN2A/GluN2B subunit ratio at synaptic sites in PD patients compared to control subjects (Figures 3A,C, TIF fraction; GluN2A/GluN2B PD vs. C: ***p < 0.001, two-tailed unpaired Student’s t-test). Here, GRIN2A is linked to Parkinson disease.