INS and type 2 diabetes mellitus: 2000). Aldosterone excess produced insulin resistance in animals and humans (Colussi et al. 2007), could be progressed to overt type 2 diabetes mellitus (Kahn et al. 2006). In addition, Mosso et al. (2007) observed an inverse relation between insulin secretion and aldosterone levels in hypertensive patients. Furthermore, blockade of the renin–angiotensinogen–aldosterone system has beneficial effects on glucose homeostasis through unknown mechanism (McMurray et al. 2010).