IL6 and acute pancreatitis: 2014). Thus, the significant rise of IL6 found in the 8-week high salt fed group could explain the pancreatic damage observed histopathologically, in the form of fibrosis and acinar distortion, and functional impairment evidenced by decreased plasma levels of amylase and lipase. Sathyanarayan et al. (2007) reported that increased IL6 levels could predict organ failure and severe pancreatitis, and they suggested its pathophysiological significance in acute pancreatitis.