Fibrosis of pancreas observed in 8-week high salt diet fed group as evidenced by impairment of exocrine and endocrine pancreatic functions, and also, by histological finding of ductal and acinar fibrosis, could be due to high plasma levels of TGF-β1 and IL6, and not due to plasma aldosterone which was decreased significantly. This evidence concerns the gene TGFB1 and fibrosis.