2006). Moreover, as Cianchi et al. (2006) reported, 5-LOX inhibition increases the antitumor activity of COX inhibitors in human colon cancer cells. These findings support the hypothesis that the key elements of the AA cascade are involved in the regulation of intestinal epithelial structure/function (Ferrer and Moreno 2010). This evidence concerns the gene ALOX5 and malignant colon neoplasm.