SPATA18 and small intestine neoplasm: As shown in Fig. 7c, compared with the ApcMin/+ mice, there was a substantial increase in both nitrotyrosine and 8-OHdG immunopositivity in the small intestinal tumors of the ApcMin/+ Mieap−/− mice (Fig. 7c) and the ApcMin/+ Mieap+/− mice (Supplementary Fig. S5).