SPATA18 and adenocarcinoma: We confirmed that the number of high-grade adenomas (Category 2) and adenocarcinomas (Category 3) in the small intestine (Fig. 5a), colon (Fig. 5b), and whole intestine (Fig. 5c) was substantially increased in accordance with the Mieap gene deletion in the ApcMin/+ mice (Fig. 5a–c).