To explain the malignant progression mediated by Mieap deficiency in intestinal tumors, we speculated that there was crosstalk between Mieap-mediated mitochondrial quality control and the Hippo pathway because it has been reported that mitochondrial dysfunction stimulated ROS production and inactivated the Hippo pathway through c-Jun amino (N)-terminal kinase (JNK) signaling48. Here, MAPK8 is linked to intestinal neoplasm.