SPATA18 and neoplasm: Since Mieap is a critical regulator of mitochondrial quality control2, 3, 4, and Mieap deficiency leads to an accumulation of unhealthy mitochondria and an increase in mtROS in vitro2, 3, we speculated that the accumulation of unhealthy mitocnondria and upregulation of oxidative stress in the intestine and tumor may be involved in the mechanism for the promoted tumor malignant progression in the Mieap-deficient ApcMin/+ mice.