SPATA18 and adenoma: In contrast to the Category 1 tumors, there were diversely shaped atypical/distorted glandular structures (Fig. 5e,g, upper panels) composed of dysplastic tumor cells with an increased N/C ratio (Fig. 5e,g, lower panels with insets) in the high-grade adenomas (Category 2) of the ApcMin/+ Mieap+/− (Fig. 5e) and ApcMin/+ Mieap−/− (Fig. 5g) mice.