The importance of autophagic signaling for osteoclastogenesis was first realized when it was discovered that mutations in the ubiquitin binding protein p62/SQSTM1 was implicated in Paget’s Disease of Bone (PDB), a disease associated with rapid bone remodeling and weakness due to aberrant osteoclastogenesis [5]. Here, SQSTM1 is linked to bone Paget disease.