Consistent with our finding that reduced platelet aggregation in septic shock was not a consequence of reduced ROK-mediated Thr855 phosphorylation of MYPT was the observation that aggregation was also attenuated in response to collagen and ADP, agonists thought to activate platelets independent of Gα12/13 and RhoA/ROK [34]. The gene discussed is RHOA; the disease is Shock.