The depletion of CD25+ T cells induced autoimmune gastritis in nude recipients,3 while that of CD45RBlow T cells resulted in colitis in Rag-deficient or SCID recipients.10 Later, Foxp3 expression was found better correlated with CD25+ than CD45RBlow, establishing Tregs as CD25+Foxp3+ T cells.2, 3. This evidence concerns the gene FOXP3 and colitis.