FOXP3 and colitis: Tbx21-deficient Foxp3+ T cells fail to suppress the Th1-type inflammation of a Foxp3 hypomorphic mutant, scurfy mice.47 Similarly, the Foxp3+ T cell-specific deletion of Irf4, which is required for Th2 differentiation, results in the dysregulation of Th2 response,48 and Foxp3+ T cell-specific deletion of a Th17 factor, Stat3, results in a Th17-mediated colitis.