Among the variants present in the two brothers possibly contributing to autism was a missense variant in SCN2A, also present in their unaffected sister, as well as a missense variant in CACNA1H gene, encoding a calcium channel, and missense variant in FOXP2, encoding a forkhead-box DNA-binding domain containing transcription factor required for proper development of speech and language, which are both inherited from the healthy mother (Table S3). The gene discussed is CACNA1H; the disease is autism.