Among the variants present in the two brothers possibly contributing to autism was a missense variant in SCN2A, also present in their unaffected sister, as well as a missense variant in CACNA1H gene, encoding a calcium channel, and missense variant in FOXP2, encoding a forkhead-box DNA-binding domain containing transcription factor required for proper development of speech and language, which are both inherited from the healthy mother (Table S3). This evidence concerns the gene SCN2A and autism.