However, Massa F et al. observed that although both NT and EGF enhance colonic epithelial cells growth, the intracellular pathways involved in these effects are quite independent and NT is unable to transactivate EGFR in two cell lines, HT29 and HCT116 [33], in contrast to results obtained in other colonic and prostatic cancer cell lines [27, 34]. The gene discussed is EGF; the disease is Familial prostate cancer.