FOXA1 and neoplasm: Furthermore FOXA1 and GATA3 are frequently downregulated in basal tumour but rarely over-expressed or amplified in luminal cancer (Fig. S11) [44] while PBX1 is among the top upregulated genes and is frequently amplified in luminal cancers (Figs. 4–5, S6, S8, S10 and S11).