For example, SgK223 promotes cell invasion in colon carcinoma cells exhibiting high Src activity [21], while overexpression of SgK269 promotes growth and aberrant morphogenesis of MCF-10A mammary epithelial cells, and is required for epithelial-to-mesenchymal transition (EMT) and anchorage-independent growth of basal breast cancer cells [19]. The gene discussed is PRAG1; the disease is breast carcinoma.