With additional adjustment for SI in a fourth (mechanistic) model, the significant inverse association of caffeinated coffee with ALT remained, however the association with AST and NAFLD liver fat score was attenuated to non-significance (Table 3, model 4: ALT β = −0.08, p = 0.0400; AST β = −0.03, p = 0.20; NAFLD liver fat score β = −0.03, p = 0.27). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.