Since free fatty acids from the diet are the primary ligands for PPARs and one of the mechanisms driving diabetes induced cardiomyopathy, we hypothesized that MuRF3−/− mice would exhibit an enhanced cardiomyopathy and cardiac hypertrophy given MuRF3’s role in regulating PPARs and potentially SRF in vivo. Here, TRIM54 is linked to cardiomyopathy.