IGHE and allergic disease: On the other hand, the best predictive model of IgE-mediated allergy (BCR 73%; 95%CI: 56.9%; 89%) was obtained from a 1-Nearest Neighbour[14] based on clinical parameters only (number of allergic first degree relatives, tobacco exposure of the mother during pregnancy, exclusive breastfeeding at 2, 6 and 12 month visits, delivery mode, and presence of pets during pregnancy).