In order to study a potential correlation between cytokine production and the development of allergy, we measured the production of various cytokines by CBMCs or PBMCs following a non-specific stimulation with LPS or PHA on a reduced set of patients (15 IgE-mediated allergic, 30 non-IgE-mediated allergic or uncertain and 86 non-allergic). Here, IGHE is linked to allergic disease.